{"id":348,"date":"2020-10-12T08:53:16","date_gmt":"2020-10-12T08:53:16","guid":{"rendered":"https:\/\/crs.izoo.krakow.pl\/wiki\/?post_type=docs&p=348"},"modified":"2024-03-21T10:38:56","modified_gmt":"2024-03-21T10:38:56","slug":"osla-stopa-mule-foot","status":"publish","type":"docs","link":"https:\/\/crs.izoo.krakow.pl\/wiki\/docs\/osla-stopa-mule-foot\/","title":{"rendered":"O\u015bla stopa – Mule Foot"},"content":{"rendered":"\n

O\u015bla stopa nazywana r\u00f3wnie\u017c powszechnie syndaktyli\u0105, oznacza zro\u015bni\u0119te ze sob\u0105 palce. Zwierz\u0119ta wykazuj\u0105ce t\u0119 mutacj\u0119 posiadaj\u0105 kopyta bez podzia\u0142u na palce. Mog\u0105 wyst\u0119powa\u0107 na pojedynczej racicy lub w wi\u0119kszej ilo\u015bci. Mimo i\u017c zaburzenie nie prowadzi do \u015bmierci, obni\u017ca dobrostan zwierz\u0105t i prowadzi do kulawizny.<\/p>\n\n\n\n

Choroba ta dotyka wiele ras byd\u0142a. Najcz\u0119\u015bciej wyst\u0119puje u rasy holszty\u0144sko-fryzyjskiej ale pojawia si\u0119 r\u00f3wnie\u017c w takich rasa jak Angus oraz simentalska. Za podstaw\u0119 genetyczn\u0105 tego zaburzenia podaje si\u0119 mutacj\u0119 w obr\u0119bie genu LRP4 na chromosomie 15 (BTA15), maj\u0105c\u0105 kluczowe znaczenie w po\u0142\u0105czeniach nerwowo-mi\u0119\u015bniowych. Syndaktylia jest mutacj\u0105 recesywn\u0105. Wyst\u0119puje u osobnik\u00f3w homozygotycznych z dwoma allelami determinuj\u0105cymi chorob\u0119. Nosiciele natomiast nie wykazuj\u0105 objaw\u00f3w fenotypowych defektu.<\/p>\n\n\n\n

Wynik<\/strong><\/td>Interpretacja<\/strong><\/td><\/tr>
MFS<\/td>CHORY<\/td><\/tr>
MFC<\/td>NOSICIEL<\/td><\/tr>
MFF<\/td>ZDROWY<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

LITERATURA<\/h2>\n\n\n\n
    \n
  1. Duchesne A., Gautier M., Chadi S., Grohs C., Floriot S., Gallard Y., Caste G., Ducos A. i Eggen A. (2006). Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle.<\/em> Genomics 88(5), 610-621.
    <\/li>\n\n\n\n
  2. Eager K., Cauchi M., Willet C., H\u00e4fliger I, Dr\u00f6gem\u00fcller C., O’Rourke B. i Tammen I. (2021). The previously reported LRP4 c.4940C>T variant is not associated with syndactyly in cattle. <\/em>Anim Genet 52(3):380-381.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    O\u015bla stopa nazywana r\u00f3wnie\u017c powszechnie syndaktyli\u0105, oznacza zro\u015bni\u0119te ze sob\u0105 palce. Zwierz\u0119ta wykazuj\u0105ce t\u0119 mutacj\u0119 posiadaj\u0105 kopyta bez podzia\u0142u na palce. Mog\u0105 wyst\u0119powa\u0107 na pojedynczej racicy lub w wi\u0119kszej ilo\u015bci. […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"doc_category":[17],"doc_tag":[18,7],"class_list":["post-348","docs","type-docs","status-publish","hentry","doc_category-lista-cech","doc_tag-cecha-genetyczna","doc_tag-snp"],"_links":{"self":[{"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/docs\/348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/docs"}],"about":[{"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/types\/docs"}],"author":[{"embeddable":true,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/comments?post=348"}],"version-history":[{"count":7,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/docs\/348\/revisions"}],"predecessor-version":[{"id":1651,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/docs\/348\/revisions\/1651"}],"wp:attachment":[{"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/media?parent=348"}],"wp:term":[{"taxonomy":"doc_category","embeddable":true,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/doc_category?post=348"},{"taxonomy":"doc_tag","embeddable":true,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/doc_tag?post=348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}