{"id":1447,"date":"2023-04-03T07:42:10","date_gmt":"2023-04-03T07:42:10","guid":{"rendered":"https:\/\/crs.izoo.krakow.pl\/wiki\/?post_type=docs&#038;p=1447"},"modified":"2024-03-21T10:40:57","modified_gmt":"2024-03-21T10:40:57","slug":"syndactyly-mule-foot","status":"publish","type":"docs","link":"https:\/\/crs.izoo.krakow.pl\/wiki\/en\/docs\/syndactyly-mule-foot\/","title":{"rendered":"Syndactyly &#8211; Mule Foot"},"content":{"rendered":"\n<p>Mule foot, also commonly called syndactyly, means toes fused together. Animals exhibiting this mutation have hooves without toe separation. They can occur on a single hoof or in more than one. Although the disorder does not lead to death, it reduces animal welfare and leads to lameness.<\/p>\n\n\n\n<p>The disease affects many breeds of cattle. Most common in the Holstein-Friesian breed but also appears in breeds such as Angus and Simmental. The genetic basis of the disorder is cited as a mutation within the LRP4 gene, which is crucial in neuromuscular connections. Syndactyly is a recessive mutation. It occurs in individuals who are homozygous with two disease-determining alleles. Carriers, on the other hand, show no phenotypic symptoms of the defect.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table><tbody><tr><td><strong>Result<\/strong><\/td><td><strong>Interpretation<\/strong><\/td><\/tr><tr><td>MFS<\/td><td>SICK<\/td><\/tr><tr><td>MFC<\/td><td>CARRIER<\/td><\/tr><tr><td>MFF<\/td><td>FREE<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">REFERENCES<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Duchesne A., Gautier M., Chadi S., Grohs C., Floriot S., Gallard Y., Caste G., Ducos A. &amp; Eggen A. (2006). <em>Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle.<\/em> Genomics 88(5), 610-621.<br><\/li>\n\n\n\n<li>Eager K., Cauchi M., Willet C., H\u00e4fliger I, Dr\u00f6gem\u00fcller C., O&#8217;Rourke B. &amp; Tammen I. (2021). <em>The previously reported LRP4 c.4940C>T variant is not associated with syndactyly in cattle. <\/em>Anim Genet 52(3):380-381.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Mule foot, also commonly called syndactyly, means toes fused together. Animals exhibiting this mutation have hooves without toe separation. They can occur on a single hoof or in more than [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"doc_category":[75],"doc_tag":[85,88],"class_list":["post-1447","docs","type-docs","status-publish","hentry","doc_category-list-of-genetic-tratis","doc_tag-genetic-trait","doc_tag-snp"],"_links":{"self":[{"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/docs\/1447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/docs"}],"about":[{"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/types\/docs"}],"author":[{"embeddable":true,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/comments?post=1447"}],"version-history":[{"count":2,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/docs\/1447\/revisions"}],"predecessor-version":[{"id":1653,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/docs\/1447\/revisions\/1653"}],"wp:attachment":[{"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/media?parent=1447"}],"wp:term":[{"taxonomy":"doc_category","embeddable":true,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/doc_category?post=1447"},{"taxonomy":"doc_tag","embeddable":true,"href":"https:\/\/crs.izoo.krakow.pl\/wiki\/wp-json\/wp\/v2\/doc_tag?post=1447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}